Thiazole for light yellow with corruption stink liquid, boiling point 116.8 ℃, relative density 1.998 (17/4 ℃). Thiazole and pyridine similar, with weak alkaline; But with picric acid and hydrochloric acid to form a salt, etc, and many metal chloride (such as gold chloride, etc) to form complex, and has certain melting point. Thiazole ring system has certain stability, also show some of the aromaticity. It and pyridine in the chemical nature similar, for example, two of the hydrogen is active; Can also with sodium amide effect, generation 2 - amino thiazole; The amine can also be diazotization (see diazotization reaction). Thiazole generally cannot be reduced to two hydrogen and four hydrogen compounds.
A variety of thiazole derivatives is an important drug or physiological active substances. Penicillin molecule contains a four hydrogen thiazole ring system. Vitamin B1 molecules of thiazole part is a quaternary ammonium salt derivatives. We use many vulcanization accelerator, such as 2 - acetyl thiazole is thiazole derivatives. Important bacteriostatic agent sulfathiazole is 2 - amino thiazole and ethyl amide group benzene sulfonyl chloride condensation (see condensation reaction), then get the hydrolysis reaction of the product. Many thiazole derivatives is synthesis of amino acid, purine of reagentUsed for organic synthesis reagent, used for synthetic drugs, dye, rubber accelerator, film former, fungicide and dye, etc
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