What is HOBt(mono hydrate) used for?

Hydroxybenzotriazole (abbreviated HOBt) is an organic compound that is a derivative of benzotriazole. It is mainly used to suppress racemization and improve the efficiency of peptide synthesis. It is a white crystalline powder. Commercial HOBt always contains some water (~11.7% wt as the HOBt monohydrate crystal) because anhydrous HOBt is explosive.
Use of HOBt(mono hydrate)
Automated peptide synthesis involves the condensation of the amino group of protected amino acids with the activated ester. HOBt is used to produce such activated esters. These esters are insoluble (like the N-hydroxysuccinimide esters) and react with amines at ambient temperature to give amides.
HOBt is also used for the synthesis of amides from carboxylic acids aside from amino acids. These substrates may not be convertable to the acyl chlorides. For instance amide derivatives of ionophoric antibiotics have been prepared in this way.
Together with laccase, HOBt is also used for bleaching pulps. The method is still on the experimental stage and have yet not been commercialized.
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