CAS No.:35737-15-6
Molecular formula:C26H22N2O4
Molecular weight:426.5
Description of Fmoc-Trp-OH
Purity (HPLC):98.5% min.
Appearance:White powder
Melting point:184~186 ℃
Specific rotation(20/D):28o (c=1, DMF)
Solid appearance peptide amalgam (SPPS) has been the a lot of able adjustment for the alertness of peptides back its addition in 1963 by Bruce Merrifield. The t-Boc amino acerbic derivatives had been acclimated dominantly for the SPPS until the Fmoc allure was alien to affected the t-Boc allure problems, repetitive TFA analysis which ability activate the ancillary reactions and carve the peptide alternation prematurely. In Fmoc synthesis, the growing peptide is subjected to balmy abject analysis application piperidine to abolish the Fmoc group, and TFA is appropriate alone for the final deprotection and break from the resin. The allegory abstracts amid Fmoc and t-Boc approache announce that Fmoc allure is added reliable and tends to accord the adapted peptides in bigger purities.
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