CAS Number: 39968-33-7
Molecular Weight: 136.11
Molecular Formula: C5H4N4O
Physical Appearance: White Solid
Solubility: Soluble in Methanol and Water
concentration 0.5-0.7 M in DMF
refractive index n20/D 1.4390
1-Hydroxy-7-azabenzotriazole, commonly abbreviated HOAt, is a triazole used as a peptide coupling reagent. It suppresses the loss of chirality.
1-Hydroxybenzotriazole (HOBt) and 1-hydroxy-7-aza-benzotriazole (HOAt) are substances that react with the O-acylurea to form active esters. HOAt is a condensation additive in peptide synthesis. It efficiently speeds up coupling process, reduces the loss of chiral integrity, and provides a visual indication (yellow to colorless) of the reaction course.
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